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Subodh Film producer, director, writer, and an actor.. : 6. 18. Aap Kaa Surroor 2 – Ae Himesh Bhai Hindi Dubbed Download 720p. abdul rahaman.Formulation and in vitro evaluation of furosemide-loaded PLGA-based microparticles.
The aim of the present study is to examine the potential of the biodegradable polymeric microparticles as a suitable carrier for the delivery of furosemide. Furosemide was loaded into poly(D,L-lactide-co-glycolide) (PLGA) matrix by double emulsion technique. The drug loaded microparticles were prepared by the solvent evaporation technique and evaluated for their globule size, morphology, drug entrapment efficiency and in vitro drug release. Drug release study was carried out in simulated gastrointestinal fluids (SGF) using U.S.P. Type 1 apparatus. The produced microparticles were globular in shape with an average diameter between 0.3-5 μm. Drug entrapment efficiency was found to be around 80-90% with some burst effect and was considered to be in the safe region for oral application. Drug release from furosemide microparticles followed modified zero order release pattern in SGF. Prepared formulation showed a sustained release pattern in which the drug is slowly released into the gastrointestinal tract. It was found to be suitable carrier for delivery of furosemide, and would be a promising strategy to deliver water insoluble drugs orally.Historical and Current
Haleakala – Mountain of Fire and Ice
The explosive release of Haleakala Volcano in the eastern half of the island of Hawaii, resulted in a period of sustained eruptions known as the summit-flood eruption from 1887 to 1891 that altered the shape of the coastline, and destroyed vast numbers of homes and other structures. During the 1923 eruption, a much larger volume of lava was erupted than during earlier explosions at the summit, and, in total, five giant craters were formed on the volcano’s east flank. During the late 1960’s to early 1970’s, the mountain generated much more explosive activity, with overflows of new craters and massive lava flows reaching the ocean in the east. The mountain has continued to erupt sporadically, with a more characteristic snow-like activity at its summit appearing in
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